We study cancer-fighting T cells to develop new immunotherapies for brain tumors.

From pediatric gliomas to adult glioblastoma, our work translates immunology into therapies for aggressive neuro-oncology. We’re a new lab, building actively, with a translational orientation from day one.

We are recruiting graduate students, postdocs, and rotation students.

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Target discovery

Decoding the immune dialogue

We decode the complex dialogue between brain tumors and the immune system using sequencing and bioinformatic techniques to uncover the specific evasion mechanisms that current therapies miss.

Raphael et al. Sci Transl Med. 2025

Cellular cross-talk

Reprogramming the tumor-immune niche

We study how the extreme conditions of the brain tumor microenvironment dictate the success or failure of an immune response — and what reprograms it.

Raphael et al. Front Immunol. 2021

Precision immunotherapy

Designing next-generation therapies

Rationally combinatorial approaches, from TCR-engineered T cells to vaccines, designed to overcome the immunosuppressive microenvironment for robust tumor elimination.

Xiong et al. Cell Mol Immunol. 2026